Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells

BACKGROUND: Methotrexate is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for different types of cancer and other disorders. The usefulness of treatment with metho...

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Bibliographic Details
Main Authors: Selga, Elisabet, Morales, Cristina, Noé, Véronique, Peinado, Miguel A, Ciudad, Carlos J
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527490/
https://ncbi.nlm.nih.gov/pubmed/18694510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-1-35
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