Differential effects of ifosfamide on dendritic cell-mediated stimulation of T cell interleukin-2 production, natural killer cell cytotoxicity and interferon-γ production

Ifosfamide is a DNA-alkylating agent used frequently in chemotherapy of human malignancies. Ifosfamide and its major decomposition products deplete intracellular glutathione (GSH). Glutathione is the major intracellular thiol reductant that protects cells against oxidative injury. Ifosfamide depleti...

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Bibliographic Details
Main Authors: Kuppner, M C, Bleifuß, E, Noessner, E, Mocikat, R, von C Hesler, Mayerhofer, C, Issels, R D
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2008
Subjects:
Basic Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527363/
https://ncbi.nlm.nih.gov/pubmed/18647323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03708.x
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