Growth Hormone Deficiency and Splicing Fidelity: TWO SERINE/ARGININE-RICH PROTEINS, ASF/SF2 AND SC35, ACT ANTAGONISTICALLY

The majority of mutations that cause isolated growth hormone deficiency type II are the result of aberrant splicing of transcripts encoding human growth hormone. Such mutations increase skipping of exon 3 and encode a 17.5-kDa protein that acts as a dominant negative to block secretion of full-lengt...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Solis, Amanda S., Peng, Rui, Crawford, J. Barrett, Phillips, John A., Patton, James G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
RNA: Processing and Catalysis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527097/
https://ncbi.nlm.nih.gov/pubmed/18586677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710175200
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