Tissue Transglutaminase Contributes to Interstitial Renal Fibrosis by Favoring Accumulation of Fibrillar Collagen through TGF-β Activation and Cell Infiltration

Renal fibrosis is defined by the exaggerated accumulation of extracellular matrix proteins. Tissue transglutaminase (TG2) modifies the stability of extracellular matrix proteins and renders the extracellular matrix resistant to degradation. In addition, TG2 also activates transforming growth factor-...

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Detalhes bibliográficos
Main Authors: Shweke, Nasim, Boulos, Nada, Jouanneau, Chantal, Vandermeersch, Sophie, Melino, Gerry, Dussaule, Jean-Claude, Chatziantoniou, Christos, Ronco, Pierre, Boffa, Jean-Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527082/
https://ncbi.nlm.nih.gov/pubmed/18688035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080025
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