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Efficient Transplantation via Antibody-based Clearance of Hematopoietic Stem Cell Niches
We demonstrate that administration of a depleting antibody specific for c-kit leads to the highly efficient removal of host hematopoietic stem cells (HSCs) and high levels of donor HSC chimerism following transplantation. Upon intravenous transplantation, hematopoietic stem cells (HSCs) can home to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527021/ https://ncbi.nlm.nih.gov/pubmed/18033883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1149726 |
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