Osteopontin Mediates Stat1 Degradation To Inhibit iNOS Transcription In A Cecal Ligation and Puncture Model of Sepsis

BACKGROUND: Osteopontin (OPN) represses inducible nitric oxide synthase (iNOS) expression by increasing ubiquitin (Ub)-proteasome degradation of Stat1, a critical transcription factor for iNOS expression. We investigated the in vivo relevance of our findings in a cecal ligation and puncture (CLP) mo...

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Main Authors: Guo, Hongtao, Wai, Philip Y., Mi, Zhiyong, Gao, Chengjiang, Zhang, Jinping, Kuo, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525867/
https://ncbi.nlm.nih.gov/pubmed/18656624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2008.03.007
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