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A New Bisintercalating Anthracycline with Picomolar DNA Binding Affinity

A new bisintercalating anthracycline (WP762) has been designed, in which monomeric units of daunorubicin have been linked through their amino groups on the daunosamine moieties using an m-xylenyl linker. Differential scanning calorimetry and UV melting experiments were used to measure the ultratight...

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Main Authors: Portugal, José, Cashman, Derek J., Trent, John O., Ferrer-Miralles, Neus, Przewloka, Teresa, Fokt, Izabela, Priebe, Waldemar, Chaires, Jonathan B.
格式: Artigo
語言:Inglês
出版: 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522373/
https://ncbi.nlm.nih.gov/pubmed/16366602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050902g
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