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A New Bisintercalating Anthracycline with Picomolar DNA Binding Affinity
A new bisintercalating anthracycline (WP762) has been designed, in which monomeric units of daunorubicin have been linked through their amino groups on the daunosamine moieties using an m-xylenyl linker. Differential scanning calorimetry and UV melting experiments were used to measure the ultratight...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2522373/ https://ncbi.nlm.nih.gov/pubmed/16366602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050902g |
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