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Identification and Quantification of a Guanine-thymine Intrastrand Crosslink Lesion Induced by Cu(II)/H(2)O(2)/Ascorbate
Reactive oxygen species (ROS) can be induced by both endogenous and exogenous processes and they can damage biological molecules including nucleic acids. It was shown that X- or γ-ray irradiation of aqueous solutions of DNA, during which (·)OH is one of the major ROS, can lead to the formation of in...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519820/ https://ncbi.nlm.nih.gov/pubmed/16696563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060025x |
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