Exploring the Interaction of Ruthenium(II) Polypyridyl Complexes with DNA Using Single-Molecule Techniques

Here we explore DNA binding by a family of ruthenium(II) polypyridyl complexes using an atomic force microscope (AFM) and optical tweezers. We demonstrate using AFM that Ru(bpy)(2)dppz(2+) intercalates into DNA (K(b)= 1.5 × 10(5) M(−1)), as does its close relative Ru(bpy)(2)dppx(2+) (K(b)= 1.5 × 10(...

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Main Authors: Mihailovic, Aleksandra, Vladescu, Ioana, McCauley, Micah, Ly, Elaine, Williams, Mark C., Spain, Eileen M., Nuñez, Megan E.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519805/
https://ncbi.nlm.nih.gov/pubmed/16649785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la053242r
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