Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain

Changes in the envelope proteins of retroviruses can alter the ability of these viruses to infect the central nervous system (CNS) and induce neurological disease. In the present study, nine envelope residues were found to influence neurovirulence of the Friend murine polytropic retrovirus Fr98. Whe...

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Autori principali: Peterson, Karin E., Pourciau, Susan, Du, Min, LaCasse, Rachel, Pathmajeyan, Melissa, Poulsen, David, Agbandje-McKenna, Mavis, Wehrly, Kathy, Chesebro, Bruce
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519673/
https://ncbi.nlm.nih.gov/pubmed/18579597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02134-07
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