Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain

Changes in the envelope proteins of retroviruses can alter the ability of these viruses to infect the central nervous system (CNS) and induce neurological disease. In the present study, nine envelope residues were found to influence neurovirulence of the Friend murine polytropic retrovirus Fr98. Whe...

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Detalhes bibliográficos
Main Authors: Peterson, Karin E., Pourciau, Susan, Du, Min, LaCasse, Rachel, Pathmajeyan, Melissa, Poulsen, David, Agbandje-McKenna, Mavis, Wehrly, Kathy, Chesebro, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519673/
https://ncbi.nlm.nih.gov/pubmed/18579597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02134-07
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