Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain

Changes in the envelope proteins of retroviruses can alter the ability of these viruses to infect the central nervous system (CNS) and induce neurological disease. In the present study, nine envelope residues were found to influence neurovirulence of the Friend murine polytropic retrovirus Fr98. Whe...

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Autores principales: Peterson, Karin E., Pourciau, Susan, Du, Min, LaCasse, Rachel, Pathmajeyan, Melissa, Poulsen, David, Agbandje-McKenna, Mavis, Wehrly, Kathy, Chesebro, Bruce
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519673/
https://ncbi.nlm.nih.gov/pubmed/18579597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02134-07
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