CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type 1 (HIV-1) infection. To better define the underlying mechanisms, we studied the magnitude of alpha IFN (IFN-α) induction by recombinant viruses containing changes in th...

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Detalhes bibliográficos
Main Authors: Haupt, Sabrina, Donhauser, Norbert, Chaipan, Chawaree, Schuster, Philipp, Puffer, Bridget, Daniels, Rod S., Greenough, Thomas C., Kirchhoff, Frank, Schmidt, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519661/
https://ncbi.nlm.nih.gov/pubmed/18579609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00196-08
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