Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2

Human metapneumovirus (HMPV) is a major causative agent of severe bronchiolitis and pneumonia. Its fusion (F) protein must be cleaved by host proteases to cause membrane fusion, a critical step for virus infection. By generating Vero cells constitutively expressing the transmembrane serine protease...

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Main Authors: Shirogane, Yuta, Takeda, Makoto, Iwasaki, Masaharu, Ishiguro, Nobuhisa, Takeuchi, Hiroki, Nakatsu, Yuichiro, Tahara, Maino, Kikuta, Hideaki, Yanagi, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519639/
https://ncbi.nlm.nih.gov/pubmed/18562527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00676-08
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