Application of a Novel, Rapid, and Sensitive Oligonucleotide Ligation Assay for Detection of Cancer-Predicting Mutations in the Precore and Basal Core Promoter of Hepatitis B Virus

Hepatocellular carcinoma (HCC) and cirrhosis are important causes of mortality worldwide. Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are assoc...

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Detalles Bibliográficos
Main Authors: Mendy, M. E., Kaye, S., Le Roux, E., Kirk, G. D., Jeng-Barry, A., McConkey, S., Cotten, M., Kuniholm, M. H., Leligdowicz, A., Hainaut, P., Rowland-Jones, S., Whittle, H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Virology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519494/
https://ncbi.nlm.nih.gov/pubmed/18508941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01622-07
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