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Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine
Gag-CD8(+) T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Δ4 Nef(+)), creating Δ5 Nef(-), would affect his immunogenicity. When compared with Δ4...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519121/ https://ncbi.nlm.nih.gov/pubmed/18586360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.05.057 |
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