Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

Human embryonic stem cells (hESCs) are a valuable source of pluripotential primary cells. To date, however, their homogeneous cellular differentiation to specific cell types in vitro has proven difficult. Wnt signaling has been shown to play important roles in coordinating development, and we demons...

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Detalhes bibliográficos
Main Authors: Hay, David C., Fletcher, Judy, Payne, Catherine, Terrace, John D., Gallagher, Ronald C. J., Snoeys, Jan, Black, James R., Wojtacha, Davina, Samuel, Kay, Hannoun, Zara, Pryde, Anne, Filippi, Celine, Currie, Ian S., Forbes, Stuart J., Ross, James A., Newsome, Philip N., Iredale, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518825/
https://ncbi.nlm.nih.gov/pubmed/18719101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806522105
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