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N-Acetylcholinesterase-Induced Apoptosis in Alzheimer's Disease
BACKGROUND: Alzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended “synaptic” acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena. METHODOLOGY AND PRINCI...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518620/ https://ncbi.nlm.nih.gov/pubmed/18769671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003108 |
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