Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in cure rates, prediction of disease outcome remains a major challenge and survivors suffer from serious therapy-related side-effects. Recent data showed that patients with WNT-activated tum...

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Main Authors: Kool, Marcel, Koster, Jan, Bunt, Jens, Hasselt, Nancy E., Lakeman, Arjan, van Sluis, Peter, Troost, Dirk, Meeteren, Netteke Schouten-van, Caron, Huib N., Cloos, Jacqueline, Mršić, Alan, Ylstra, Bauke, Grajkowska, Wieslawa, Hartmann, Wolfgang, Pietsch, Torsten, Ellison, David, Clifford, Steven C., Versteeg, Rogier
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518524/
https://ncbi.nlm.nih.gov/pubmed/18769486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003088
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