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Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

OBJECTIVE— Melanocortin-4 receptor (MC4R) deficiency is the most frequent genetic cause of obesity. However, there is uncertainty regarding the degree of penetrance of this condition, and the putative impact of the environment on the development of obesity in MC4R mutation carriers is unknown. RESEA...

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Detalhes bibliográficos
Main Authors: Stutzmann, Fanny, Tan, Karen, Vatin, Vincent, Dina, Christian, Jouret, Béatrice, Tichet, Jean, Balkau, Beverley, Potoczna, Natascha, Horber, Fritz, O'Rahilly, Stephen, Farooqi, I. Sadaf, Froguel, Philippe, Meyre, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518504/
https://ncbi.nlm.nih.gov/pubmed/18559663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0153
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