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Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

OBJECTIVE—The G-protein–coupled receptor Gpr40 is expressed in β-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion (1–4). However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 w...

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Autors principals: Edfalk, Sara, Steneberg, Pär, Edlund, Helena
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518478/
https://ncbi.nlm.nih.gov/pubmed/18519800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0307
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