Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

KIT is a member of the tyrosine kinase family of growth factor receptors which is expressed on a variety of haematopoietic cells including mast cells. Stem cell factor (SCF)-dependent activation of KIT is critical for mast cell homeostasis and function. However, when KIT is inappropriately activated...

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Bibliographic Details
Main Authors: Jensen, B M, Akin, C, Gilfillan, A M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
Subjects:
Reviews
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518463/
https://ncbi.nlm.nih.gov/pubmed/18500355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.204
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