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Infrequent Translation of a Nonsense Codon Is Sufficient to Decrease mRNA Level

In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD). Although previous analyzes have shown that conditions that impede translation termination at nonse...

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Библиографические подробности
Главные авторы: Buzina, Alla, Shulman, Marc J.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 1999
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC25184/
https://ncbi.nlm.nih.gov/pubmed/10069800
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