ELEVATED LIPID PEROXIDATION AND DNA OXIDATION IN NERVE FROM DIABETIC RATS: EFFECTS OF ALDOSE REDUCTASE INHIBITION, INSULIN AND NEUROTROPHIC FACTORS

We investigated the effect of treatment with an aldose reductase inhibitor, insulin or select neurotrophic factors on the generation of oxidative damage in peripheral nerve. Rats were either treated with streptozotocin (STZ) to induce insulin-deficient diabetes or fed with a diet containing 40% D-ga...

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Bibliographic Details
Main Authors: Cunha, Joice M., Jolivalt, Corinne G., Ramos, Khara M., Gregory, Joshua A., Calcutt, Nigel A., Mizisin, Andrew P.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518323/
https://ncbi.nlm.nih.gov/pubmed/18555826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2008.01.021
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