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Intermediate filament protein synemin contributes to the migratory properties of astrocytoma cells by influencing the dynamics of the actin cytoskeleton

We have shown previously that, in astrocytoma cells, synemin is present at the leading edge, an unusual localization for an intermediate filament (IF) protein. Here, we report that synemin down-regulation with specific small hairpin RNAs (shRNAs) sharply decreased the migration of astrocytoma cells....

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Hlavní autoři: Pan, Yihang, Jing, Runfeng, Pitre, Aaron, Williams, Briana Jill, Skalli, Omar
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518255/
https://ncbi.nlm.nih.gov/pubmed/18509200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-106187
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