Beneficial Effect of TRAIL on HIV Burden, without Detectable Immune Consequences

BACKGROUND: During uncontrolled HIV disease, both TNF-related apoptosis inducing ligand (TRAIL) and TRAIL receptor expression are increased. Enhanced TRAIL sensitivity is due to TRAIL receptor up-regulation induced by gp120. As a result of successful antiretroviral therapy TRAIL is down-regulated, a...

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Main Authors: Shepard, Brett D., De Forni, Davide, McNamara, David R., Foli, Andrea, Rizza, Stacey A., Abraham, Roshini S., Knutson, Keith, Wettstein, Peter J., Lori, Franco, Badley, Andrew D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517653/
https://ncbi.nlm.nih.gov/pubmed/18769477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003096
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