Aberrant Transforming Growth Factor β1 Signaling and SMAD4 Nuclear Translocation Confer Epigenetic Repression of ADAM19 in Ovarian Cancer

Transforming growth factor-beta (TGF-β)/SMAD signaling is a key growth regulatory pathway often dysregulated in ovarian cancer and other malignancies. Although loss of TGF-β-mediated growth inhibition has been shown to contribute to aberrant cell behavior, the epigenetic consequence(s) of impaired T...

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Hlavní autoři: Chan, Michael WY, Huang, Yi-Wen, Hartman-Frey, Corinna, Kuo, Chieh-Ti, Deatherage, Daniel, Qin, Huaxia, Cheng, Alfred SL, Yan, Pearlly S, Davuluri, Ramana V, Huang, Tim H-M, Nephew, Kenneth P, Lin, Huey-Jen L
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517635/
https://ncbi.nlm.nih.gov/pubmed/18714391
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