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Clinical implications of the basic defects in Cockayne Syndrome and xeroderma pigmentosum and the DNA lesions responsible for cancer, neurodegeneration and aging

Cancer, aging, and neurodegeneration are all associated with DNA damage and repair in complex fashions. Aging appears to be a cell and tissue-wide process linked to the insulin-dependent pathway in several DNA repair deficient disorders, especially in mice. Cancer and neurodegeneration appear to hav...

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Detalhes bibliográficos
Main Authors: Cleaver, J.E., Revet, I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517418/
https://ncbi.nlm.nih.gov/pubmed/18336867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2008.01.005
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