Interaction of Fibroblast Growth Factor-2 (FGF-2) with Free Gangliosides: Biochemical Characterization and Biological Consequences in Endothelial Cell Cultures

Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor-2 (FGF-2), but their mechanism of action has not been elucidated. Here, a possible direct interaction of sialo-glycolipids with FGF-2 has been investigated. Size exclusion chromatography demonstrates that native, but n...

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Main Authors: Rusnati, Marco, Tanghetti, Elena, Urbinati, Chiara, Tulipano, Giovanni, Marchesini, Sergio, Ziche, Marina, Presta, Marco
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25171/
https://ncbi.nlm.nih.gov/pubmed/9950679
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