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The Effects of Reversibility and Noise on Stochastic Phosphorylation Cycles and Cascades

The phosphorylation-dephosphorylation cycle is a common motif in cellular signaling networks. Previous work has revealed that, when driven by a noisy input signal, these cycles may exhibit bistable behavior. Here, a recently introduced theorem on network bistability is applied to prove that the exis...

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Autori principali: Miller, Clark A., Beard, Daniel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517037/
https://ncbi.nlm.nih.gov/pubmed/18515389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.126185
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