The Catalytic and Lectin Domains of UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Function in Concert to Direct Glycosylation Site Selection

UDP-GalNAc:polypeptide α-N-Acetylgalactosaminyltransferases (ppGalNAcTs), a family (EC 2.4.1.41) of enzymes that initiate mucin-type O-glycosylation, are structurally composed of a catalytic domain and a lectin domain. Previous studies have suggested that the lectin domain modulates the glycosylatio...

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Bibliographische Detailangaben
Hauptverfasser: Raman, Jayalakshmi, Fritz, Timothy A., Gerken, Thomas A., Jamison, Oliver, Live, David, Liu, Mian, Tabak, Lawrence A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517002/
https://ncbi.nlm.nih.gov/pubmed/18562306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803387200
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