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Impact of DNA Hairpin Folding Energetics on Antibody - ssDNA Association
Deposition of anti-DNA antibodies in the kidney contributes to the pathogenesis of the autoimmune disease, systemic lupus erythematosus. Antibodies that bind to hairpin-forming DNA ligands may be particularly prone to deposition. Here we report the first structure of a Fab complexed with hairpin-for...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516951/ https://ncbi.nlm.nih.gov/pubmed/18028946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.09.084 |
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