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Stereocontrolled Synthesis of Functionalized cis-Cyclopentapyrazolidines by 1,3-Dipolar Cycloaddition Reactions of Azomethine Imines

The reaction of alkene-tethered α-ketocarboxylic acid derivatives with monosubstituted hydrazines allows highly substituted cis-cyclopentapyrazolidine ring systems 4 to be constructed rapidly. Successful cyclocondensations are realized under thermal reaction conditions; in some cases, protic or Lewi...

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Autors principals: Gergely, Joshua, Morgan, Jeremy B., Overman, Larry E.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516743/
https://ncbi.nlm.nih.gov/pubmed/17109540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo061537j
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