Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-κB pathways and promotes osteoclastogenesis in human oral cancer cells

Oral squamous cell carcinoma (SCC) has a striking tendency to invade to bone. The chemokine stromal cell-derived factor-1 (SDF-1) is constitutively secreted by osteoblasts and plays a key role in homing of hematopoietic cells to the bone marrow. Interleukin (IL)-6 plays an important role in osteocla...

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Hlavní autoři: Tang, Chih-Hsin, Chuang, Jing-Yuan, Fong, Yi-Chin, Maa, Ming-Chei, Way, Tzong-Der, Hung, Chien-Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516485/
https://ncbi.nlm.nih.gov/pubmed/18310089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn045
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