Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

Telomere dysfunction limits the proliferative capacity of human cells by activation of DNA damage responses, inducing senescence or apoptosis. In humans, telomere shortening occurs in the vast majority of tissues during aging, and telomere shortening is accelerated in chronic diseases that increase...

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Detalhes bibliográficos
Main Authors: Jiang, Hong, Schiffer, Eric, Song, Zhangfa, Wang, Jianwei, Zürbig, Petra, Thedieck, Kathrin, Moes, Suzette, Bantel, Heike, Saal, Nadja, Jantos, Justyna, Brecht, Meiken, Jenö, Paul, Hall, Michael N., Hager, Klaus, Manns, Michael P., Hecker, Hartmut, Ganser, Arnold, Döhner, Konstanze, Bartke, Andrzej, Meissner, Christoph, Mischak, Harald, Ju, Zhenyu, Rudolph, K. Lenhard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516278/
https://ncbi.nlm.nih.gov/pubmed/18695223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801457105
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