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Incorporation of Y′-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants
Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y′ repeats generates chimeric Y′-Ty1 cDNA. Here, we show that Y′-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric inc...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Genetics Society of America
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516100/ https://ncbi.nlm.nih.gov/pubmed/18660531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.089052 |
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