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Incorporation of Y′-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants

Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y′ repeats generates chimeric Y′-Ty1 cDNA. Here, we show that Y′-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric inc...

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Autors principals: Maxwell, Patrick H., Curcio, M. Joan
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516100/
https://ncbi.nlm.nih.gov/pubmed/18660531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.089052
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