COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson’s disease (PD): relevance for motor and non-motor features

Levodopa is the most effective treatment in Parkinson’s disease and the association with COMT inhibitors widens its plasma bioavailability and effectiveness. Tolcapone is a potent COMT inhibitor whose utilization in PD is limited due to safety concerns on liver toxicity. However, recent data indicat...

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Bibliografiske detaljer
Main Authors: Antonini, Angelo, Abbruzzese, Giovanni, Barone, Paolo, Bonuccelli, Ubaldo, Lopiano, Leonardo, Onofrj, Marco, Zappia, Mario, Quattrone, Aldo
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2008
Fag:
Expert Opinion
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515921/
https://ncbi.nlm.nih.gov/pubmed/18728767
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