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Youden Index and Optimal Cut-Point Estimated from Observations Affected by a Lower Limit of Detection

The receiver operating characteristic (ROC) curve is used to evaluate a biomarker’s ability for classifying disease status. The Youden Index (J), the maximum potential effectiveness of a biomarker, is a common summary measure of the ROC curve. In biomarker development, levels may be unquantifiable b...

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Autors principals: Ruopp, Marcus D., Perkins, Neil J., Whitcomb, Brian W., Schisterman, Enrique F.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515362/
https://ncbi.nlm.nih.gov/pubmed/18435502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.200710415
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