New steroidal aromatase inhibitors: Suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death

BACKGROUND: Aromatase, the cytochrome P-450 enzyme (CYP19) responsible for estrogen biosynthesis, is an important target for the treatment of estrogen-dependent breast cancer. In fact, the use of synthetic aromatase inhibitors (AI), which induce suppression of estrogen synthesis, has shown to be an...

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Hlavní autoři: Cepa, Margarida, Correia-da-Silva, Georgina, da Silva, Elisiário J Tavares, Roleira, Fernanda MF, Borges, Margarida, Teixeira, Natércia A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515307/
https://ncbi.nlm.nih.gov/pubmed/18652661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-9-41
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