DNA-Free Recombinant SV40 Capsids Protect Mice from Acute Renal Failure by Inducing Stress Response, Survival Pathway and Apoptotic Arrest

Viruses induce signaling and host defense during infection. Employing these natural trigger mechanisms to combat organ or tissue failure is hampered by harmful effects of most viruses. Here we demonstrate that SV40 empty capsids (Virus Like Particles-VLPs), with no DNA, induce host Hsp/c70 and Akt-1...

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Main Authors: Butin-Israeli, Veronika, Uzi, Dotan, Abd-El-Latif, Mahmoud, Pizov, Galina, Eden, Arieh, Haviv, Yosef S., Oppenheim, Ariella
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515219/
https://ncbi.nlm.nih.gov/pubmed/18714386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002998
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