Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound

VAF347 is a low-molecular-weight compound that inhibits allergic lung inflammation in vivo. This effect is likely the result of a block of dendritic cell (DC) function to generate proinflammatory T-helper (Th) cells because VAF347 inhibits interleukin (IL)–6, CD86, and human leukocyte antigen (HLA)–...

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Bibliografische gegevens
Hoofdauteurs: Lawrence, B. Paige, Denison, Michael S., Novak, Hermann, Vorderstrasse, Beth A., Harrer, Nathalie, Neruda, Wolfgang, Reichel, Claudia, Woisetschläger, Maximilian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2008
Onderwerpen:
Immunobiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515129/
https://ncbi.nlm.nih.gov/pubmed/18270326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-109645
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