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Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells

Alveolar rhabdomyosarcoma (ARMS) cells often harbor one of two unique chromosomal translocations, either t(2;13)(q35;q14) or t(1;13)(p36;q14). The chimeric proteins expressed from these rearrangements, PAX3-FKHR and PAX7-FKHR, respectively, are potent transcriptional activators. In an effort to expl...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Massuda, Edmond S., Dunphy, Edward J., Redman, Rebecca A., Schreiber, Jennifer J., Nauta, Lauren E., Barr, Frederic G., Maxwell, Ian H., Cripe, Timothy P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25098/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405676/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14701
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