Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells

Alveolar rhabdomyosarcoma (ARMS) cells often harbor one of two unique chromosomal translocations, either t(2;13)(q35;q14) or t(1;13)(p36;q14). The chimeric proteins expressed from these rearrangements, PAX3-FKHR and PAX7-FKHR, respectively, are potent transcriptional activators. In an effort to expl...

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Bibliographische Detailangaben
Hauptverfasser: Massuda, Edmond S., Dunphy, Edward J., Redman, Rebecca A., Schreiber, Jennifer J., Nauta, Lauren E., Barr, Frederic G., Maxwell, Ian H., Cripe, Timothy P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25098/
https://ncbi.nlm.nih.gov/pubmed/9405676
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