Reactivation of a methylation-silenced gene in adenovirus-transformed cells by 5-azacytidine or by E1A trans activation.

In the adenovirus type 2 (Ad2)-transformed hamster cell line HE3, the integrated late E2A promoter of Ad2 DNA is inactive, is methylated at all three 5'-CCGG-3' sequences, and can be reactivated by growing the cells in the presence of 50 microM 5-azacytidine (5-azaC). The three 5'-CCGG-3' sequences...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Knust, B, Brüggemann, U, Doerfler, W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250931/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2473219/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.8.3519-3524.1989
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