Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis.

We have constructed vaccinia virus recombinants expressing dengue virus proteins from cloned DNA for use in experimental immunoprophylaxis. A recombinant virus containing a 4.0-kilobase DNA sequence that codes for three structural proteins, capsid (C), premembrane (pre-M), and envelope (E), and for...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Bray, M, Zhao, B T, Markoff, L, Eckels, K H, Chanock, R M, Lai, C J
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1989
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2724416/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.6.2853-2856.1989
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