Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus.

EBNA1 activates the EBV plasmid maintenance sequence oriP by binding to its two essential regions. One region is a family of 30-base-pair (bp) repeats and is activated by EBNA1 to act as a transcriptional enhancer. The other region contains a 65-bp dyad symmetry and lacks enhancer function. To explo...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Wysokenski, D A, Yates, J L
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 1989
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250751/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2542579/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.6.2657-2666.1989
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