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N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state.

Scrapie and related transmissible spongiform encephalopathies result in the accumulation of a protease-resistant form of an endogenous brain protein called PrP. As an approach to understanding the scrapie-associated modification of PrP, we have studied the processing and sedimentation properties of...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Caughey, B, Raymond, G J, Ernst, D, Race, R E
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 1991
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250721/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1682507/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.12.6597-6603.1991
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