The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.
Simian virus 40 (SV40) T antigen binds to the tumor suppressor p53 protein, and this association may contribute to oncogenic transformation by the virus. We investigated the importance of this binding on transformation by examining three replication-competent mutants of SV40 (402DE, 402DN, and 402DH...
Sparad:
| I publikationen: | J Virol |
|---|---|
| Huvudupphov: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
American Society for Microbiology (ASM)
1991
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250682/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658353/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.12.6447-6453.1991 |
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