The proteolytic cleavage of PE2 to envelope glycoprotein E2 is not strictly required for the maturation of Sindbis virus.

The ionophore monensin has been shown previously to block the maturation of Sindbis virus as well as prevent the cleavage of pE2 to E2 when applied to cells in high concentration. We found that a moderate dose of monensin reduced virus titer and inhibited the cleavage of pE2 to E2. Under these condi...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Presely, J F, Brown, D T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2704073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.5.1975-1980.1989
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