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Synthesis of a Biotin Derivative of Iberiotoxin: Binding Interactions with Streptavidin and the BK Ca(2+)-activated K(+) Channel Expressed in a Human Cell Line
Iberiotoxin (IbTx) is a scorpion venom peptide that inhibits BK Ca(2+)-activated K(+) channels with high affinity and specificity. Automated solid phase synthesis was used to prepare a biotin-labeled derivative (IbTx-LC-biotin) of IbTx by substitution of Asp19 of the native 37-residue peptide with N...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2505059/ https://ncbi.nlm.nih.gov/pubmed/16704206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc060002u |
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