Synthesis and Pharmacological Evaluation of Novel 9- and 10- Substituted Cytisine Derivatives - Nicotinic Ligands of Enhanced Subtype Selectivity

We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the α4β2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was found to have a very similar agonist activity pro...

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Bibliographic Details
Main Authors: Chellappan, Sheela K., Xiao, Yingxian, Tueckmantel, Werner, Kellar, Kenneth J., Kozikowski, Alan P.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504867/
https://ncbi.nlm.nih.gov/pubmed/16640326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm051196m
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