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Transition state for protein–DNA recognition
We describe the formation of protein–DNA contacts in the two-state route for DNA sequence recognition by a transcriptional regulator. Surprisingly, direct sequence readout establishes in the transition state and constitutes the bottleneck of complex formation. Although a few nonspecific ionic intera...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504826/ https://ncbi.nlm.nih.gov/pubmed/18664582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802383105 |
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