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Transition state for protein–DNA recognition

We describe the formation of protein–DNA contacts in the two-state route for DNA sequence recognition by a transcriptional regulator. Surprisingly, direct sequence readout establishes in the transition state and constitutes the bottleneck of complex formation. Although a few nonspecific ionic intera...

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Hlavní autoři: Ferreiro, Diego U., Sánchez, Ignacio E., de Prat Gay, Gonzalo
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504826/
https://ncbi.nlm.nih.gov/pubmed/18664582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802383105
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