Disruption of Lateral Olivocochlear Neurons via a Dopaminergic Neurotoxin Depresses Sound-Evoked Auditory Nerve Activity

We applied the dopaminergic (DA) neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the guinea pig cochlear perilymph. Immunolabeling of lateral olivocochlear (LOC) neurons using antibodies against synaptophysin was reduced after the MPTP treatment. In contrast, labeling of the medial...

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Bibliografiske detaljer
Main Authors: Le Prell, Colleen G., Halsey, KÄrin, Hughes, Larry F., Dolan, David F., Bledsoe, Sanford C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2005
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504639/
https://ncbi.nlm.nih.gov/pubmed/15735934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10162-004-5009-2
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